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Indirubin E804

CAS No. 854171-35-0

Indirubin E804 ( E804 )

Catalog No. M16204 CAS No. 854171-35-0

An indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Indirubin E804
  • Note
    Research use only, not for human use.
  • Brief Description
    An indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells.
  • Description
    An indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells, directly inhibits Src kinase activity (IC50=0.43 uM) in vitro; decreases tyrosyl phosphorylation of Stat3, suppresses constitutive Stat3 DNA binding-activity in treated cells, also down-regulates antiapoptotic proteins Mcl-1 and Survivin; inhibits the subintestinal vessels formation in zebrafish embryos.
  • Synonyms
    E804
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    854171-35-0
  • Formula Weight
    365.39
  • Molecular Formula
    C20H19N3O4
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC=C2C(=C1)C(=C(N2)O)C3=NC4=CC=CC=C4C3=NOCCC(CO)O
  • Chemical Name
    3-[3-[(3,4-Dihydroxybutoxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Nam S, et al. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5998-6003.
2. Zhou J, et al. Blood. 2009 Apr 23;113(17):4052-62.
3. Chan YK, et al. Biochem Pharmacol. 2012 Mar 1;83(5):598-607.
4. Nam S, et al. Mol Oncol. 2012 Jun;6(3):276-83.
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