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Indirubin E804
CAS No. 854171-35-0
Indirubin E804( E804 )
Catalog No. M16204 CAS No. 854171-35-0
An indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 100MG | Get Quote | In Stock |
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| 200MG | Get Quote | In Stock |
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| 500MG | Get Quote | In Stock |
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| 1G | Get Quote | In Stock |
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Biological Information
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Product NameIndirubin E804
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NoteResearch use only, not for human use.
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Brief DescriptionAn indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells.
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DescriptionAn indirubin derivative that potently blocks constitutive STAT3 signaling in human breast and prostate cancer cells, directly inhibits Src kinase activity (IC50=0.43 uM) in vitro; decreases tyrosyl phosphorylation of Stat3, suppresses constitutive Stat3 DNA binding-activity in treated cells, also down-regulates antiapoptotic proteins Mcl-1 and Survivin; inhibits the subintestinal vessels formation in zebrafish embryos.
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In VitroIndirubin Derivative E804 is a water-soluble indirubin derivative as potent inhibitor of Insulin-like Growth Factor 1 Receptor (IGF1R), with an IC50 of 0.65 μM. Indirubin Derivative E804 also inhibits CDK2/CycE with an EC50 of 0.23 μM.
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In Vivo——
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SynonymsE804
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT
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Research Area——
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Indication——
Chemical Information
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CAS Number854171-35-0
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Formula Weight365.389
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Molecular FormulaC20H19N3O4
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (342.11 mM)
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SMILESC1=CC=C2C(=C1)C(=C(N2)O)C3=NC4=CC=CC=C4C3=NOCCC(CO)O
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Chemical Name3-[3-[(3,4-Dihydroxybutoxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-1,3-dihydro-2H-indol-2-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Nam S, et al. Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5998-6003.
2. Zhou J, et al. Blood. 2009 Apr 23;113(17):4052-62.
3. Chan YK, et al. Biochem Pharmacol. 2012 Mar 1;83(5):598-607.
4. Nam S, et al. Mol Oncol. 2012 Jun;6(3):276-83.
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